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Crystal structure of of PDE2-inhibitor complex

Source organism: Homo sapiens
Biochemical function: phosphoric diester hydrolase activity
Biological process: signal transduction
Cellular component: not assigned

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EC 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase

Reaction catalysed:
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate
Systematic name:
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Alternative Name(s):
  • 3', 5'-cyclic nucleoside monophosphate phosphodiesterase
  • 3',5'-cyclonucleotide phosphodiesterase
  • 3',5'-nucleotide phosphodiesterase
  • 3': 5'-monophosphate phosphodiesterase (cyclic CMP)
  • 3':5'-cyclic nucleotide 5'-nucleotidohydrolase
  • Cyclic 3',5'-mononucleotide phosphodiesterase
  • Cyclic 3',5'-nucleotide phosphodiesterase
  • Cyclic 3',5'-phosphodiesterase
  • Cyclic 3',5-nucleotide monophosphate phosphodiesterase
  • Cyclic AMP phosphodiesterase
  • Cyclic nucleotide phosphodiesterase
  • Cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP)
  • Nucleoside 3',5'-cyclic phosphate diesterase
  • Nucleoside-3',5-monophosphate phosphodiesterase
  • PDE

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00233
Domain description: 3'5'-cyclic nucleotide phosphodiesterase
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
The deposited structure of PDB entry 4jib contains 4 copies of Pfam domain PF00233 (3'5'-cyclic nucleotide phosphodiesterase) in cGMP-dependent 3',5'-cyclic phosphodiesterase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023088
Domain description: 3'5'-cyclic nucleotide phosphodiesterase
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
IPR003607
Domain description: HD/PDEase domain
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
IPR002073
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
IPR023174
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
IPR036971
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase

Structure domain

CATH CATH domain
1.10.1300.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homology: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
The deposited structure of PDB entry 4jib contains 4 copies of CATH domain 1.10.1300.10 (Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b) in cGMP-dependent 3',5'-cyclic phosphodiesterase. Showing 1 copy in chain A.

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