› 4jle

X-ray diffraction
2.35Å resolution

Structure of the P. falciparum PFI1780w PHIST domain

Released:
DOI: 10.2210/pdb4jle/pdb
PDB entry 4jle coloured by chain, front view.
PDB entry 4jle coloured by chain, side view.
PDB entry 4jle coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface.
Oberli A, Slater LM, Cutts E, Brand F, Mundwiler-Pachlatko E, Rusch S, Masik MF, Erat MC, Beck HP, Vakonakis I
OpenAccess logo FASEB J 28 4420-33 (2014)
PMID: 24983468

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-184642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasmodium RESA N-terminal domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 20.52 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I2F2 (Residues: 85-247; Coverage: 43%)
Gene name: PF3D7_0936800
Sequence domains: Plasmodium RESA N-terminal
Structure domains: Plasmodium RESA, N-terminal helical domain

Ligands and Environments

2 bound ligands:
Ligand CL 6 x CL
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3121
Unit cell:
a: 71.03Å b: 71.03Å c: 146.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria.
Wahlgren et al. (2017)
15 more

3 mentions without citation

A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface.
Oberli et al. (2014)
2 more