› 4jvh

X-ray diffraction
3.5Å resolution

Structure of the star domain of quaking protein in complex with RNA

Released:
DOI: 10.2210/pdb4jvh/pdb
PDB entry 4jvh coloured by chain, front view.
PDB entry 4jvh coloured by chain, side view.
PDB entry 4jvh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.
Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel DJ
Genes Dev 27 928-40 (2013)
PMID: 23630077

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188681 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
KH domain-containing RNA-binding protein QKI Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 24.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96PU8 (Residues: 7-214; Coverage: 61%)
Gene names: HKQ, QKI
Sequence domains:
Structure domains: K Homology domain, type 1
RNA (5'-R(*UP*UP*CP*AP*CP*UP*AP*AP*CP*AP*A)-3') Chain: D
Molecule details ›
Chain: D
Length: 11 nucleotides
Theoretical weight: 3.44 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6122
Unit cell:
a: 98.634Å b: 98.634Å c: 103.137Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.243 0.316
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

18 review citations

Past, present, and future of circRNAs.
Patop et al. (2019)
17 more

10 mentions without citation

The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease.
Liao et al. (2016)
9 more