› 4k41

X-ray diffraction
1.4Å resolution

Crystal structure of actin in complex with marine macrolide kabiramide C

Released:
DOI: 10.2210/pdb4k41/pdb
PDB entry 4k41 coloured by chain, front view.
PDB entry 4k41 coloured by chain, side view.
PDB entry 4k41 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues.
Pereira JH, Petchprayoon C, Hoepker AC, Moriarty NW, Fink SJ, Cecere G, Paterson I, Adams PD, Marriott G
ChemMedChem 9 2286-93 (2014)
PMID: 25047814

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 41.86 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CA 2 x CA
Ligand ATP 1 x ATP
Ligand KAB 1 x KAB
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 58.355Å b: 55.553Å c: 104.1Å
α: 90° β: 92.77° γ: 90°
R-values:
R R work R free
0.169 0.168 0.194

Quick links

Citations

2 review citations

Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton.
Gao et al. (2022)
1 more

2 mentions without citation

Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues.
Pereira et al. (2014)
1 more