Function and Biology

Poliovirus polymerase elongation complex (r5_form)

Source organism: Human poliovirus 1 Mahoney
Biochemical function: RNA-dependent RNA polymerase activity
Biological process: viral RNA genome replication
Cellular component: not assigned

EC 3.4.22.29: Picornain 2A

Reaction catalysed:
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
Systematic name:
-
Alternative Name(s):
  • 2A protease
  • 2A proteinase
  • Picornaviral 2A proteinase
  • Picornavirus endopeptidase 2A
  • Poliovirus protease 2A
  • Poliovirus protease 2A-Pro
  • Poliovirus proteinase 2A
  • Protease 2A
  • Proteinase 2A-Pro
  • Rhinovirus protease 2A
  • Y-G proteinase 2A

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.22.28: Picornain 3C

Reaction catalysed:
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Alternative Name(s):
  • 3C protease
  • 3C proteinase
  • Coxsackievirus 3C proteinase
  • Cysteine proteinase 3C
  • Foot-and-mouth protease 3C
  • Foot-and-mouth-disease virus proteinase 3C
  • Hepatitis A virus 3C proteinase
  • Picornavirus endopeptidase 3C
  • Poliovirus protease 3C
  • Poliovirus proteinase 3C
  • Protease 3C
  • Rhinovirus protease 3C
  • Rhinovirus proteinase 3C
  • Tomato ringspot nepovirus 3C-related protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00680
Domain description: Viral RNA-dependent RNA polymerase
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 4k4u contains 2 copies of Pfam domain PF00680 (Viral RNA-dependent RNA polymerase) in RNA-directed RNA polymerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR043128
Domain description: Reverse transcriptase/Diguanylate cyclase domain
Occurring in:
  1. RNA-directed RNA polymerase
IPR007094
Domain description: RNA-directed RNA polymerase, catalytic domain
Occurring in:
  1. RNA-directed RNA polymerase
IPR001205
Domain description: RNA-directed RNA polymerase, C-terminal domain
Occurring in:
  1. RNA-directed RNA polymerase
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. RNA-directed RNA polymerase

Structure domains

CATH CATH domains
3.30.70.270
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 4k4u contains 2 copies of CATH domain 3.30.70.270 (Alpha-Beta Plaits) in RNA-directed RNA polymerase. Showing 1 copy in chain A.
1.20.960.20
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Mitochondrial Import Receptor Subunit Tom20; Chain A
Homology: Mitochondrial Import Receptor Subunit Tom20; Chain A
Occurring in:
  1. RNA-directed RNA polymerase
The deposited structure of PDB entry 4k4u contains 2 copies of CATH domain 1.20.960.20 (Mitochondrial Import Receptor Subunit Tom20; Chain A) in RNA-directed RNA polymerase. Showing 1 copy in chain A.