› 4k70

X-ray diffraction
2Å resolution

Crystal Structure of N-terminal half of Pseudorabiesvirus UL37 protein

Released:
DOI: 10.2210/pdb4k70/pdb
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PDB entry 4k70 coloured by chain, front view.
PDB entry 4k70 coloured by chain, side view.
PDB entry 4k70 coloured by chain, top view.
Source organism: Suid alphaherpesvirus 1
Primary publication:
Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking.
Pitts JD, Klabis J, Richards AL, Smith GA, Heldwein EE
J Virol 88 5462-73 (2014)
PMID: 24599989

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187481 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UL37 tegument protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 500 amino acids
Theoretical weight: 53.57 KDa
Source organism: Suid alphaherpesvirus 1
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q911W0 (Residues: 1-496; Coverage: 54%)
Gene names: UL37, ul37
Sequence domains: Herpesvirus UL37 tegument protein

Ligands and Environments

5 bound ligands:
Ligand GOL 2 x GOL
Ligand CA 6 x CA
Ligand NA 21 x NA
Ligand CL 5 x CL
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 51.67Å b: 156.589Å c: 67.381Å
α: 90° β: 91.33° γ: 90°
R-values:
R R work R free
0.175 0.173 0.22
Expression system: Escherichia coli BL21

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Citations

7 review citations

Tegument Assembly and Secondary Envelopment of Alphaherpesviruses.
Owen et al. (2015)
6 more

7 mentions without citation

The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion.
Richards et al. (2017)
6 more

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