› 4kcd

X-ray diffraction
1.68Å resolution

Crystal Structure of the NMDA Receptor GluN3A Ligand Binding Domain Apo State

Released:
DOI: 10.2210/pdb4kcd/pdb
PDB entry 4kcd coloured by chain, front view.
PDB entry 4kcd coloured by chain, side view.
PDB entry 4kcd coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Conformational analysis of NMDA receptor GluN1, GluN2, and GluN3 ligand-binding domains reveals subtype-specific characteristics.
Yao Y, Belcher J, Berger AJ, Mayer ML, Lau AY
Structure 21 1788-99 (2013)
PMID: 23972471

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 3A Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 32.94 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9R1M7 (Residues: 511-660, 776-915; Coverage: 26%)
Gene name: Grin3a
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 75.029Å b: 83.885Å c: 99.139Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.154 0.184
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Structure, function, and allosteric modulation of NMDA receptors.
Hansen et al. (2018)
16 more

2 mentions without citation

Conformational analysis of NMDA receptor GluN1, GluN2, and GluN3 ligand-binding domains reveals subtype-specific characteristics.
Yao et al. (2013)
1 more