› 4kds

X-ray diffraction
1.67Å resolution

Crystal structure of latent rainbow trout plasminogen activator inhibitor 1 (PAI-1)

Released:
DOI: 10.2210/pdb4kds/pdb
PDB entry 4kds coloured by chain, front view.
PDB entry 4kds coloured by chain, side view.
PDB entry 4kds coloured by chain, top view.
Source organism: Oncorhynchus mykiss
Primary publication:
Protein conformational change delayed by steric hindrance from an N-linked glycan.
Bager R, Johansen JS, Jensen JK, Stensballe A, Jendroszek A, Buxbom L, Sørensen HP, Andreasen PA
J Mol Biol 425 2867-77 (2013)
PMID: 23702291

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 386 amino acids
Theoretical weight: 43.09 KDa
Source organism: Oncorhynchus mykiss
Expression system: Escherichia coli
UniProt:
  • Canonical: I3WWD7 (Residues: 15-391; Coverage: 100%)
Gene names: PAI, PAI-1, PAI1, PLANH1, serpine1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P21
Unit cell:
a: 58.065Å b: 56.471Å c: 59.75Å
α: 90° β: 93.88° γ: 90°
R-values:
R R work R free
0.175 0.172 0.218
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Functional stability of plasminogen activator inhibitor-1.
Yasar Yildiz et al. (2014)
1 more

1 mention without citation

Serine protease inhibitors of the whirling disease parasite Myxobolus cerebralis (Cnidaria, Myxozoa): Expression profiling and functional predictions.
Eszterbauer et al. (2021)