› 4kf3

X-ray diffraction
1.92Å resolution

Crystal Structure of Myotoxin II (MjTX-II), a myotoxic Lys49-phospholipase A2 from Bothrops moojeni.

Released:
DOI: 10.2210/pdb4kf3/pdb
PDB entry 4kf3 coloured by chain, front view.
PDB entry 4kf3 coloured by chain, side view.
PDB entry 4kf3 coloured by chain, top view.
Source organism: Bothrops moojeni
Primary publication:
Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A₂-like.
Salvador GH, Cavalcante WL, Dos Santos JI, Gallacci M, Soares AM, Fontes MR
Toxicon 72 52-63 (2013)
PMID: 23810946

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191507 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog myotoxin II Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 13.91 KDa
Source organism: Bothrops moojeni
UniProt:
  • Canonical: Q9I834 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

2 bound ligands:
Ligand PE4 4 x PE4
Ligand IPA 6 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P212121
Unit cell:
a: 49.999Å b: 62.169Å c: 86.007Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.257

Quick links

Citations

10 citation in other articles

Structural bases for a complete myotoxic mechanism: crystal structures of two non-catalytic phospholipases A2-like from Bothrops brazili venom.
Fernandes et al. (2013)
9 more

4 mentions without citation

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920).
Salvador et al. (2019)
3 more