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4kfj Overview
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>4kfj</span> coloured by chain, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>FOLIC ACID</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_deposited_chain_front_image-800x800.png "PDB entry 4kfj coloured by chain, front view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>4kfj</span> coloured by chain, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>FOLIC ACID</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_deposited_chain_side_image-800x800.png "PDB entry 4kfj coloured by chain, side view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>4kfj</span> coloured by chain, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>FOLIC ACID</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_deposited_chain_top_image-800x800.png "PDB entry 4kfj coloured by chain, top view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>4kfj</span> coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>FOLIC ACID</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_deposited_chemically_distinct_molecules_front_image-800x800.png "PDB entry 4kfj coloured by chemically distinct molecules, front view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>4kfj</span> coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>FOLIC ACID</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_deposited_chemically_distinct_molecules_side_image-800x800.png "PDB entry 4kfj coloured by chemically distinct molecules, side view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>4kfj</span> coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>FOLIC ACID</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_deposited_chemically_distinct_molecules_top_image-800x800.png "PDB entry 4kfj coloured by chemically distinct molecules, top view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>4kfj</span> contains 1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>. Front view.</div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_entity_3_front_image-800x800.png "6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine in PDB entry 4kfj, assembly 1, front view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>4kfj</span> coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_assembly_1_chemically_distinct_molecules_front_image-800x800.png "Monomeric assembly 1 of PDB entry 4kfj coloured by chemically distinct molecules, front view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>4kfj</span> coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_assembly_1_chemically_distinct_molecules_side_image-800x800.png "Monomeric assembly 1 of PDB entry 4kfj coloured by chemically distinct molecules, side view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>4kfj</span> coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Dihydrofolate reductase</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>CHLORIDE ION</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>ETHANOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/4kfj_assembly_1_chemically_distinct_molecules_top_image-800x800.png "Monomeric assembly 1 of PDB entry 4kfj coloured by chemically distinct molecules, top view.")