› 4kol

X-ray diffraction
2.8Å resolution

The structure of hemagglutinin from avian-origin H7N9 influenza virus

Released:
DOI: 10.2210/pdb4kol/pdb
PDB entry 4kol coloured by chain, front view.
PDB entry 4kol coloured by chain, side view.
PDB entry 4kol coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Shi Y, Zhang W, Wang F, Qi J, Wu Y, Song H, Gao F, Bi Y, Zhang Y, Fan Z, Qin C, Sun H, Liu J, Haywood J, Liu W, Gong W, Wang D, Shu Y, Wang Y, Yan J, Gao GF
Science 342 243-7 (2013)
PMID: 24009358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197610 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 34.2 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: V5IRU4 (Residues: 1-314; Coverage: 100%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 Chain: B
Molecule details ›
Chain: B
Length: 169 amino acids
Theoretical weight: 19.49 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: V5IRU3 (Residues: 1-169; Coverage: 100%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: R32
Unit cell:
a: 116.898Å b: 116.898Å c: 296.588Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.23 0.282
Expression system: Trichoplusia ni

Quick links

Citations

34 review citations

Bat-derived influenza-like viruses H17N10 and H18N11.
Wu et al. (2014)
33 more

9 mentions without citation

Development of a high-yield live attenuated H7N9 influenza virus vaccine that provides protection against homologous and heterologous H7 wild-type viruses in ferrets.
Chen et al. (2014)
8 more