› 4kom

X-ray diffraction
2.6Å resolution

The structure of hemagglutinin from avian-origin H7N9 influenza virus in complex with avian receptor analog 3'SLNLN (NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc)

Released:
DOI: 10.2210/pdb4kom/pdb
Model geometry
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PDB entry 4kom coloured by chain, front view.
PDB entry 4kom coloured by chain, side view.
PDB entry 4kom coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Shi Y, Zhang W, Wang F, Qi J, Wu Y, Song H, Gao F, Bi Y, Zhang Y, Fan Z, Qin C, Sun H, Liu J, Haywood J, Liu W, Gong W, Wang D, Shu Y, Wang Y, Yan J, Gao GF
Science 342 243-7 (2013)
PMID: 24009358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197610 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 34.2 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: V5IRU4 (Residues: 1-314; Coverage: 100%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 Chain: B
Molecule details ›
Chain: B
Length: 169 amino acids
Theoretical weight: 19.49 KDa
Source organism: Influenza A virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: V5IRU3 (Residues: 1-169; Coverage: 100%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, SIA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: R32
Unit cell:
a: 117.06Å b: 117.06Å c: 296.429Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.223 0.272
Expression system: Trichoplusia ni

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Citations

34 review citations

Role of receptor binding specificity in influenza A virus transmission and pathogenesis.
de Graaf et al. (2014)
33 more

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