› 4kp0

X-ray diffraction
2.8Å resolution

Crystal Structure of the human Chymase with TJK002

Released:
DOI: 10.2210/pdb4kp0/pdb
PDB entry 4kp0 coloured by chain, front view.
PDB entry 4kp0 coloured by chain, side view.
PDB entry 4kp0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor.
Matsumoto Y, Kakuda S, Koizumi M, Mizuno T, Muroga Y, Kawamura T, Takimoto-Kamimura M
OpenAccess logo J Synchrotron Radiat 20 914-8 (2013)
PMID: 24121339

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Phe-|- > Tyr-|- > Trp-|- > Leu-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150125 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chymase Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 25.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23946 (Residues: 22-247; Coverage: 99%)
Gene names: CMA1, CYH, CYM
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand KPK 1 x KPK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P43212
Unit cell:
a: 56.92Å b: 56.92Å c: 177.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.226 0.33
Expression system: Spodoptera frugiperda

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Citations

2 citation in other articles

Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease.
Nixon et al. (2018)
1 more

4 mentions without citation

Mast cell glycosaminoglycans.
Mulloy et al. (2017)
3 more