› 4kqz

X-ray diffraction
2.51Å resolution

structure of the receptor binding domain (RBD) of MERS-CoV spike

Released:
DOI: 10.2210/pdb4kqz/pdb
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PDB entry 4kqz coloured by chain, front view.
PDB entry 4kqz coloured by chain, side view.
PDB entry 4kqz coloured by chain, top view.
Source organism: Human betacoronavirus 2c EMC/2012
Primary publication:
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.
Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J, Zhang B, Shi Y, Yan J, Gao GF
OpenAccess logo Nature 500 227-31 (2013)
PMID: 23831647

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125454 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spike glycoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 251 amino acids
Theoretical weight: 27.6 KDa
Source organism: Human betacoronavirus 2c EMC/2012
Expression system: Trichoplusia ni
UniProt:
  • Canonical: K0BRG7 (Residues: 367-606; Coverage: 18%)
Gene name: S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 46.977Å b: 108.473Å c: 125.925Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.251
Expression system: Trichoplusia ni

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Citations

197 review citations

Origin and evolution of pathogenic coronaviruses.
Cui et al. (2019)
196 more

21 mentions without citation

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.
Hilgenfeld et al. (2013)
20 more

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