› 4l17

X-ray diffraction
2.8Å resolution

GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX

Released:
DOI: 10.2210/pdb4l17/pdb
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PDB entry 4l17 coloured by chain, front view.
PDB entry 4l17 coloured by chain, side view.
PDB entry 4l17 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
A conformational intermediate in glutamate receptor activation.
Lau AY, Salazar H, Blachowicz L, Ghisi V, Plested AJ, Roux B
Neuron 79 492-503 (2013)
PMID: 23931998

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 263 amino acids
Theoretical weight: 29.3 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand DNQ 4 x DNQ
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Unit cell:
a: 48.85Å b: 96.79Å c: 252.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.195 0.244
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
5 more

5 mentions without citation

Structural mechanism of glutamate receptor activation and desensitization.
Meyerson et al. (2014)
4 more

PDB-REDO

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