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Crystal Structure of a GH48 cellobiohydrolase from Caldicellulosiruptor bescii

Source organism: Caldicellulosiruptor bescii DSM 6725
Biochemical function: cellulase activity
Biological process: cellulose catabolic process
Cellular component: not assigned

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EC 3.2.1.4: Cellulase

Reaction catalysed:
Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans
Systematic name:
4-beta-D-glucan 4-glucanohydrolase
Alternative Name(s):
  • 1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase
  • 9.5 cellulase
  • Alkali cellulase
  • Avicelase
  • Beta-1,4-endoglucan hydrolase
  • Beta-1,4-glucanase
  • Carboxymethyl cellulase
  • Celluase A
  • Celludextrinase
  • Cellulase A 3
  • Cellulosin AP
  • Endo-1,4-beta-D-glucanase
  • Endo-1,4-beta-D-glucanohydrolase
  • Endo-1,4-beta-glucanase
  • Endoglucanase
  • Endoglucanase D
  • Pancellase SS

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02011
Domain description: Glycosyl hydrolase family 48
Occurring in:
  1. Endoglucanase
The deposited structure of PDB entry 4l6x contains 1 copy of Pfam domain PF02011 (Glycosyl hydrolase family 48) in Endoglucanase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000556
Domain description: Glycoside hydrolase, 48F
Occurring in:
  1. Endoglucanase
IPR038625
Domain description: Rhodococcus equi virulence-associated superfamily
Occurring in:
  1. Endoglucanase
IPR027390
Domain description: Endoglucanase F, domain 3
Occurring in:
  1. Endoglucanase
IPR023309
Domain description: Endoglucanase F, domain 2
Occurring in:
  1. Endoglucanase
IPR012341
Domain description: Six-hairpin glycosidase-like superfamily
Occurring in:
  1. Endoglucanase
IPR008928
Domain description: Six-hairpin glycosidase superfamily
Occurring in:
  1. Endoglucanase

Structure domains

CATH CATH domains
1.50.10.10
Class: Mainly Alpha
Architecture: Alpha/alpha barrel
Topology: Glycosyltransferase
Homology: Glycosyltransferase
Occurring in:
  1. Endoglucanase
The deposited structure of PDB entry 4l6x contains 1 copy of CATH domain 1.50.10.10 (Glycosyltransferase) in Endoglucanase. Showing 1 copy in chain A.
2.170.160.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Endo-1,4-beta-glucanase f; domain 2
Homology: Endo-1,4-beta-glucanase f. Domain 2
Occurring in:
  1. Endoglucanase
The deposited structure of PDB entry 4l6x contains 1 copy of CATH domain 2.170.160.10 (Endo-1,4-beta-glucanase f; domain 2) in Endoglucanase. Showing 1 copy in chain A.
4.10.870.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Endo-1,4-beta-glucanase f; domain 3
Homology: Endo-1,4-beta-glucanase f. Domain 3
Occurring in:
  1. Endoglucanase
The deposited structure of PDB entry 4l6x contains 1 copy of CATH domain 4.10.870.10 (Endo-1,4-beta-glucanase f; domain 3) in Endoglucanase. Showing 1 copy in chain A.

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