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Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2)

Source organism: Streptomyces coelicolor A3(2)
Biochemical function: metal ion binding
Biological process: terpene metabolic process
Cellular component: not assigned

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EC 4.2.3.118: 2-methylisoborneol synthase

Reaction catalysed:
(E)-2-methylgeranyl diphosphate + H(2)O = 2-methylisoborneol + diphosphate
Systematic name:
(E)-2-methylgeranyl diphosphate lyase (cyclizing; 2-methylisoborneol-forming)
Alternative Name(s):
  • 2-MIB cyclase
  • MIB synthase
  • MIBS
  • SCO7700 (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF19086
Domain description: Terpene synthase family 2, C-terminal metal binding
Occurring in:
  1. 2-methylisoborneol synthase
The deposited structure of PDB entry 4la5 contains 1 copy of Pfam domain PF19086 (Terpene synthase family 2, C-terminal metal binding) in 2-methylisoborneol synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. 2-methylisoborneol synthase
IPR034686
Domain description: Terpene cyclase-like 2
Occurring in:
  1. 2-methylisoborneol synthase
IPR047945
Domain description: 2-methylisoborneol synthase
Occurring in:
  1. 2-methylisoborneol synthase

Structure domain

CATH CATH domain
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. 2-methylisoborneol synthase
The deposited structure of PDB entry 4la5 contains 1 copy of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in 2-methylisoborneol synthase. Showing 1 copy in chain A.

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