› 4las

X-ray diffraction
2.33Å resolution

Crystal structure of a therapeutic single chain antibody in complex with 4-hydroxymethamphetamine

Released:
DOI: 10.2210/pdb4las/pdb
PDB entry 4las coloured by chain, front view.
PDB entry 4las coloured by chain, side view.
PDB entry 4las coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites.
Peterson EC, Celikel R, Gokulan K, Varughese KI
OpenAccess logo PLoS One 8 e82690 (2013)
PMID: 24349338

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213539 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Single chain antibody fragment scFv6H4 Chain: H
Molecule details ›
Chain: H
Length: 249 amino acids
Theoretical weight: 26.79 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand 1WF 1 x 1WF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 34.279Å b: 65.297Å c: 48.574Å
α: 90° β: 98.36° γ: 90°
R-values:
R R work R free
0.164 0.16 0.238
Expression system: Komagataella pastoris

Quick links

Citations

2 review citations

Impact of methamphetamine on infection and immunity.
Salamanca et al. (2014)
1 more

1 mention without citation

Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites.
Peterson et al. (2013)