4los

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed:
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-140780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C1s subcomponent heavy chain Chain: A
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09871 (Residues: 172-358; Coverage: 28%)
Gene name: C1S
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 66.48Å b: 69.19Å c: 76.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.212
Expression system: Escherichia coli