› 4lsd

X-ray diffraction
2.28Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Irisin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 99 amino acids
Theoretical weight: 11.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NAU1 (Residues: 33-130; Coverage: 54%)
Gene names: FNDC5, FRCP2
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P41212
Unit cell:
a: 93.2Å b: 93.2Å c: 284.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.236
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Physiology and role of irisin in glucose homeostasis.
Perakakis et al. (2017)
38 more

15 mentions without citation

Progress and Challenges in the Biology of FNDC5 and Irisin.
Maak et al. (2021)
14 more