EC 3.4.24.56: Insulysin
Reaction catalysed:
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
Alternative Name(s):
- IDE
- Insulin protease
- Insulin proteinase
- Insulin-degrading enzyme
- Insulin-degrading neutral proteinase
- Insulin-glucagon protease
- Insulin-specific protease
- Insulinase
- Metalloinsulinase
GO terms
Biochemical function:
Biological process:
- regulation of aerobic respiration
- insulin catabolic process
- insulin metabolic process
- amyloid-beta clearance by cellular catabolic process
- amyloid-beta clearance
- proteolysis involved in protein catabolic process
- amyloid-beta metabolic process
- symbiont entry into host cell
- positive regulation of protein catabolic process
- peptide catabolic process
- hormone catabolic process
- positive regulation of protein binding
- protein catabolic process
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- ubiquitin recycling
- bradykinin catabolic process
- insulin receptor signaling pathway
- proteolysis
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR003006
Domain description:
Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
Occurring in:
IPR037071
Domain description:
Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
Occurring in:
Occurring in:
CATH domains
