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Mutant structure of methyltransferase from Streptomyces hygroscopicus

Source organism: Streptomyces hygroscopicus
Biochemical function: methyltransferase activity
Biological process: methylation
Cellular component: not assigned

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EC 2.1.1.281: Phenylpyruvate C(3)-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate
Systematic name:
S-adenosyl-L-methionine:2-oxo-3-phenylpropanoate C(3)-methyltransferase
Alternative Name(s):
  • MppJ (gene name)
  • Phenylpyruvate C-beta-methyltransferase
  • Phenylpyruvate methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13649
Domain description: Methyltransferase domain
Occurring in:
  1. Phenylpyruvate C(3)-methyltransferase
The deposited structure of PDB entry 4m72 contains 2 copies of Pfam domain PF13649 (Methyltransferase domain) in Phenylpyruvate C(3)-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Phenylpyruvate C(3)-methyltransferase
IPR041698
Domain description: Methyltransferase domain 25
Occurring in:
  1. Phenylpyruvate C(3)-methyltransferase
IPR016461
Domain description: O-methyltransferase COMT-type
Occurring in:
  1. Phenylpyruvate C(3)-methyltransferase
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Phenylpyruvate C(3)-methyltransferase
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Phenylpyruvate C(3)-methyltransferase

Structure domain

CATH CATH domain
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Phenylpyruvate C(3)-methyltransferase
The deposited structure of PDB entry 4m72 contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Phenylpyruvate C(3)-methyltransferase. Showing 1 copy in chain A.

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