› 4m7i

X-ray diffraction
2.34Å resolution

Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867) at 2.34A Resolution

Released:
DOI: 10.2210/pdb4m7i/pdb
PDB entry 4m7i coloured by chain, front view.
PDB entry 4m7i coloured by chain, side view.
PDB entry 4m7i coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gampe RT, Axten JM

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192755 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 2-alpha kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZJ5 (Residues: 588-1093; Coverage: 27%)
Gene names: EIF2AK3, PEK, PERK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 27D 1 x 27D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P6122
Unit cell:
a: 101.06Å b: 101.06Å c: 158.028Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.207 0.282
Expression system: Escherichia coli

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