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ALKBH2 F102A cross-linked to undamaged dsDNA

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: DNA repair
Cellular component: not assigned

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EC 1.14.11.33: DNA oxidative demethylase

Reaction catalysed:
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)
Systematic name:
Methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)
Alternative Name(s):
  • AlkB (gene name)
  • Alkylated DNA repair protein
  • Alpha-ketoglutarate-dependent dioxygenase ABH1

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13532
Domain description: 2OG-Fe(II) oxygenase superfamily
Occurring in:
  1. DNA oxidative demethylase ALKBH2
The deposited structure of PDB entry 4mg2 contains 1 copy of Pfam domain PF13532 (2OG-Fe(II) oxygenase superfamily) in DNA oxidative demethylase ALKBH2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005123
Domain description: Oxoglutarate/iron-dependent dioxygenase domain
Occurring in:
  1. DNA oxidative demethylase ALKBH2
IPR027450
Domain description: Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Occurring in:
  1. DNA oxidative demethylase ALKBH2
IPR032852
Domain description: DNA oxidative demethylase ALKBH2
Occurring in:
  1. DNA oxidative demethylase ALKBH2
IPR037151
Domain description: Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Occurring in:
  1. DNA oxidative demethylase ALKBH2

Structure domain

CATH CATH domain
2.60.120.590
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Occurring in:
  1. DNA oxidative demethylase ALKBH2
The deposited structure of PDB entry 4mg2 contains 1 copy of CATH domain 2.60.120.590 (Jelly Rolls) in DNA oxidative demethylase ALKBH2. Showing 1 copy in chain A.

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