› 4mlp

X-ray diffraction
1.94Å resolution

Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase

Released:
DOI: 10.2210/pdb4mlp/pdb
PDB entry 4mlp coloured by chain, front view.
PDB entry 4mlp coloured by chain, side view.
PDB entry 4mlp coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase.
Nangle S, Xing W, Zheng N
OpenAccess logo Cell Res 23 1417-9 (2013)
PMID: 24080726

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cryptochrome-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 512 amino acids
Theoretical weight: 58.69 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9R194 (Residues: 1-512; Coverage: 87%)
Gene names: Cry2, Kiaa0658
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 2CX 4 x 2CX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P1
Unit cell:
a: 48.21Å b: 93.651Å c: 141.179Å
α: 89.94° β: 90.09° γ: 90.25°
R-values:
R R work R free
0.18 0.18 0.217
Expression system: Spodoptera frugiperda

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Citations

26 review citations

Transcriptional architecture of the mammalian circadian clock.
Takahashi JS. (2017)
25 more

9 mentions without citation

Photochemistry of flavoprotein light sensors.
Conrad et al. (2014)
8 more