› 4mns

X-ray diffraction
1.2Å resolution

Crystal structure of the major pollen allergen Bet v 1-A in complex with P303

Released:
DOI: 10.2210/pdb4mns/pdb
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Source organism: Betula pendula
Primary publication:
Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen-allergic patients.
Nony E, Bouley J, Le Mignon M, Lemoine P, Jain K, Horiot S, Mascarell L, Pallardy M, Vincentelli R, Leone P, Roussel A, Batard T, Abiteboul K, Robin B, de Beaumont O, Arvidsson M, Rak S, Moingeon P
Allergy 70 795-804 (2015)
PMID: 25846209

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147384 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major pollen allergen Bet v 1-A Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 17.46 KDa
Source organism: Betula pendula
Expression system: Escherichia coli
UniProt:
  • Canonical: P15494 (Residues: 2-160; Coverage: 99%)
Gene names: BETVI, BETVIA
Sequence domains: Pathogenesis-related protein Bet v 1 family
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

1 bound ligand:
Ligand 2AX 1 x 2AX
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 39.928Å b: 58.577Å c: 58.767Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.133 0.131 0.16
Expression system: Escherichia coli

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Citations

23 review citations

Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems.
Boyaka PN. (2017)
22 more

3 mentions without citation

Ligand Binding of PR-10 Proteins with a Particular Focus on the Bet v 1 Allergen Family.
Aglas et al. (2020)
2 more

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