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Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: extracellular matrix disassembly
Cellular component: collagen-containing extracellular matrix

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EC 3.4.21.59: Tryptase

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-, but with more restricted specificity than trypsin.
Alternative Name(s):
  • Lung tryptase
  • Mast cell neutral proteinase
  • Mast cell protease II
  • Mast cell proteinase II
  • Mast cell serine proteinase II
  • Mast cell serine proteinase tryptase
  • Mast cell tryptase
  • Pituitary tryptase
  • Rat mast cell protease II
  • Skin tryptase
  • Tryptase M

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Tryptase alpha/beta-1
The deposited structure of PDB entry 4mqa contains 2 copies of Pfam domain PF00089 (Trypsin) in Tryptase alpha/beta-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Tryptase alpha/beta-1
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Tryptase alpha/beta-1
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Tryptase alpha/beta-1
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Tryptase alpha/beta-1
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Tryptase alpha/beta-1
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Tryptase alpha/beta-1

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Tryptase alpha/beta-1
The deposited structure of PDB entry 4mqa contains 4 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Tryptase alpha/beta-1. Showing 2 copies in chain A.

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