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Mycobaterium tuberculosis transaminase BioA complexed with 2-hydrazinylbenzo[d]thiazole

X-ray diffraction
1.83Å resolution
PDB entry 4mqp coloured by chain, front view.
PDB entry 4mqp coloured by chain, side view.
PDB entry 4mqp coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
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Multimeric state: homo dimer
Accessible surface area: 26320.7 Å2
Buried surface area: 10553.45 Å2
Dissociation area: 4,958.45 Å2
Dissociation energy (ΔGdiss): 86.01 kcal/mol
Dissociation entropy (TΔSdiss): 15.23 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-162055
Homo dimeric assembly 1 of PDB entry 4mqp coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 4mqp coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 4mqp coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 2
Symmetry : C2
More details
3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : Interface geometry is similar to that of 3nui_1 (25% id)

Macromolecules

Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Chains: A, B
Length: 457 amino acids
Theoretical weight: 48.54 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WQ81 (Residues: 1-437; Coverage: 100%)
Gene names: MTCY336.35c, Rv1568, bioA
Pfam: Aminotransferase class-III
InterPro:
CATH:
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase in PDB entry 4mqp, assembly 1, front view.
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase in PDB entry 4mqp, assembly 1, side view.
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase in PDB entry 4mqp, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P9WQ81  
145750100150200250300350400450
 
200400
UniProt
P9WQ81
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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