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Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02758
Domain description: PAAD/DAPIN/Pyrin domain
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 14
The deposited structure of PDB entry 4n1l contains 1 copy of Pfam domain PF02758 (PAAD/DAPIN/Pyrin domain) in NACHT, LRR and PYD domains-containing protein 14. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004020
Domain description: DAPIN domain
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 14
IPR011029
Domain description: Death-like domain superfamily
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 14

Structure domain

CATH CATH domain
1.10.533.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Death Domain, Fas
Homology: Death Domain, Fas
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 14
The deposited structure of PDB entry 4n1l contains 1 copy of CATH domain 1.10.533.10 (Death Domain, Fas) in NACHT, LRR and PYD domains-containing protein 14. Showing 1 copy in chain A.

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