› 4n23

X-ray diffraction
2Å resolution

Crystal structure of the GP2 Core Domain from the California Academy of Science Virus, monoclinic symmetry

Released:
DOI: 10.2210/pdb4n23/pdb
PDB entry 4n23 coloured by chain, front view.
PDB entry 4n23 coloured by chain, side view.
PDB entry 4n23 coloured by chain, top view.
Source organism: CAS virus
Primary publication:
Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species.
Koellhoffer JF, Dai Z, Malashkevich VN, Stenglein MD, Liu Y, Toro R, S Harrison J, Chandran K, DeRisi JL, Almo SC, Lai JR
OpenAccess logo J Mol Biol 426 1452-68 (2014)
PMID: 24333483

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125337 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 130 amino acids
Theoretical weight: 15.18 KDa
Source organism: CAS virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: J7H5L9 (Residues: 257-351; Coverage: 24%)
Gene name: GPC
Structure domains: Helix Hairpins

Ligands and Environments

2 bound ligands:
Ligand MPD 4 x MPD
Ligand MRD 1 x MRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 80.866Å b: 46.718Å c: 109.474Å
α: 90° β: 104.28° γ: 90°
R-values:
R R work R free
0.179 0.176 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Novel drug discovery approaches for treating arenavirus infections.
Pasquato et al. (2016)
13 other articles

1 mention without citation

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species.
Koellhoffer et al. (2014)