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Crystal structure of Protein Arginine Deiminase 2 (D177A, 0 mM Ca2+)

Source organism: Homo sapiens
Biochemical function: histone H2AR3 arginine deiminase activity
Biological process: cellular response to leukemia inhibitory factor
Cellular component: extracellular exosome

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EC 3.5.3.15: Protein-arginine deiminase

Reaction catalysed:
Protein L-arginine + H(2)O = protein L-citrulline + NH(3)
Systematic name:
Protein-L-arginine iminohydrolase
Alternative Name(s):
  • PAD
  • Peptidylarginine deiminase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF03068
Domain description: Protein-arginine deiminase (PAD)
Occurring in:
  1. Protein-arginine deiminase type-2
The deposited structure of PDB entry 4n2h contains 1 copy of Pfam domain PF03068 (Protein-arginine deiminase (PAD)) in Protein-arginine deiminase type-2. Showing 1 copy in chain A.

PF08527
Domain description: Protein-arginine deiminase (PAD) middle domain
Occurring in:
  1. Protein-arginine deiminase type-2
The deposited structure of PDB entry 4n2h contains 1 copy of Pfam domain PF08527 (Protein-arginine deiminase (PAD) middle domain) in Protein-arginine deiminase type-2. Showing 1 copy in chain A.

PF08526
Domain description: Protein-arginine deiminase (PAD) N-terminal domain
Occurring in:
  1. Protein-arginine deiminase type-2
The deposited structure of PDB entry 4n2h contains 1 copy of Pfam domain PF08526 (Protein-arginine deiminase (PAD) N-terminal domain) in Protein-arginine deiminase type-2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036556
Domain description: Protein-arginine deiminase, central domain superfamily
Occurring in:
  1. Protein-arginine deiminase type-2
IPR013530
Domain description: Protein-arginine deiminase, C-terminal
Occurring in:
  1. Protein-arginine deiminase type-2
IPR013733
Domain description: Protein-arginine deiminase (PAD), central domain
Occurring in:
  1. Protein-arginine deiminase type-2
IPR008972
Domain description: Cupredoxin
Occurring in:
  1. Protein-arginine deiminase type-2
IPR013732
Domain description: Protein-arginine deiminase (PAD), N-terminal
Occurring in:
  1. Protein-arginine deiminase type-2
IPR004303
Domain description: Protein-arginine deiminase
Occurring in:
  1. Protein-arginine deiminase type-2
IPR038685
Domain description: PAD, N-terminal domain superfamily
Occurring in:
  1. Protein-arginine deiminase type-2

Structure domains

CATH CATH domains
3.75.10.10
Class: Alpha Beta
Architecture: 5-stranded Propeller
Topology: L-arginine/glycine Amidinotransferase; Chain A
Homology: L-arginine/glycine Amidinotransferase; Chain A
Occurring in:
  1. Protein-arginine deiminase type-2
The deposited structure of PDB entry 4n2h contains 1 copy of CATH domain 3.75.10.10 (L-arginine/glycine Amidinotransferase; Chain A) in Protein-arginine deiminase type-2. Showing 1 copy in chain A.
2.60.40.1700
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Protein-arginine deiminase, central domain
Occurring in:
  1. Protein-arginine deiminase type-2
The deposited structure of PDB entry 4n2h contains 1 copy of CATH domain 2.60.40.1700 (Immunoglobulin-like) in Protein-arginine deiminase type-2. Showing 1 copy in chain A.
2.60.40.1860
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Protein-arginine deiminase, N-terminal domain
Occurring in:
  1. Protein-arginine deiminase type-2
The deposited structure of PDB entry 4n2h contains 1 copy of CATH domain 2.60.40.1860 (Immunoglobulin-like) in Protein-arginine deiminase type-2. Showing 1 copy in chain A.

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