› 4n62

X-ray diffraction
2.5Å resolution

Crystal structure of hemagglutinin from an H7N9 influenza virus in complex with a sulfated receptor analog

Released:
DOI: 10.2210/pdb4n62/pdb
PDB entry 4n62 coloured by chain, front view.
PDB entry 4n62 coloured by chain, side view.
PDB entry 4n62 coloured by chain, top view.
Source organism: Influenza A virus (A/Shanghai/02/2013(H7N9))
Primary publication:
Preferential recognition of avian-like receptors in human influenza A H7N9 viruses.
Xu R, de Vries RP, Zhu X, Nycholat CM, McBride R, Yu W, Paulson JC, Wilson IA
Science 342 1230-5 (2013)
PMID: 24311689

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195776 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin Chains: A, C
Molecule details ›
Chains: A, C
Length: 321 amino acids
Theoretical weight: 34.99 KDa
Source organism: Influenza A virus (A/Shanghai/02/2013(H7N9))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: R4NN21 (Residues: 19-339; Coverage: 57%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin Chains: B, D
Molecule details ›
Chains: B, D
Length: 183 amino acids
Theoretical weight: 21.08 KDa
Source organism: Influenza A virus (A/Shanghai/02/2013(H7N9))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: R4NN21 (Residues: 340-515; Coverage: 31%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NGS, GAL, SIA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P213
Unit cell:
a: 153.806Å b: 153.806Å c: 153.806Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.265
Expression system: Trichoplusia ni

Quick links

Citations

31 review citations

Biological roles of glycans.
Varki A. (2017)
30 more

2 mentions without citation

New insights into influenza A specificity: an evolution of paradigms.
Ji et al. (2017)
1 more