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Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex

Source organism: Homo sapiens
Biochemical function: catalytic activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.1.71: Adenosine-5'-diphospho-5'-(DNA) diphosphatase

Reaction catalysed:
Adenosine-5'-diphospho-5'-(DNA) + H(2)O = AMP + phospho-5'-(DNA)
Systematic name:
Adenosine-5'-diphospho-5'-(DNA) hydrolase (adenosine 5'-phosphate-forming)
Alternative Name(s):
  • 5'-A-Pp5'-DNA adenylate hydrolase
  • APTX (gene name)
  • Aprataxin
  • HNT3 (gene name)

EC 3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase

Reaction catalysed:
(DNA)-3'-diphospho-5'-guanosine + H(2)O = (DNA)-3'-phosphate + GMP
Systematic name:
(DNA)-3'-diphospho-5'-guanosine hydrolase (guanosine 5'-phosphate-forming)
Alternative Name(s):
  • APTX (gene name)
  • Aprataxin
  • DNA-3'pp5'G guanylate hydrolase
  • HNT3 (gene name)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF16278
Domain description: C2HE / C2H2 / C2HC zinc-binding finger
Occurring in:
  1. Aprataxin
The deposited structure of PDB entry 4ndf contains 2 copies of Pfam domain PF16278 (C2HE / C2H2 / C2HC zinc-binding finger) in Aprataxin. Showing 1 copy in chain A.

PF11969
Domain description: Scavenger mRNA decapping enzyme C-term binding
Occurring in:
  1. Aprataxin
The deposited structure of PDB entry 4ndf contains 2 copies of Pfam domain PF11969 (Scavenger mRNA decapping enzyme C-term binding) in Aprataxin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036265
Domain description: HIT-like superfamily
Occurring in:
  1. Aprataxin
IPR013087
Domain description: Zinc finger C2H2-type
Occurring in:
  1. Aprataxin
IPR032566
Domain description: Aprataxin, C2HE/C2H2/C2HC zinc finger
Occurring in:
  1. Aprataxin
IPR019808
Domain description: Histidine triad, conserved site
Occurring in:
  1. Aprataxin
IPR011146
Domain description: HIT-like domain
Occurring in:
  1. Aprataxin

Structure domain

CATH CATH domain
3.30.428.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: HIT family, subunit A
Homology: HIT-like
Occurring in:
  1. Aprataxin
The deposited structure of PDB entry 4ndf contains 2 copies of CATH domain 3.30.428.10 (HIT family, subunit A) in Aprataxin. Showing 1 copy in chain A.

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