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Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet and 6-carboxypterin

Source organism: Burkholderia multivorans ATCC 17616
Biochemical function: S-adenosyl-L-methionine binding
Biological process: queuosine biosynthetic process
Cellular component: not assigned

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EC 4.3.99.3: 7-carboxy-7-deazaguanine synthase

Reaction catalysed:
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3)
Systematic name:
6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase
Alternative Name(s):
  • 7-carboxy-7-carbaguanine synthase
  • QueE (gene name)

GO terms

Sequence family

InterPro InterPro annotations
IPR030977
Domain description: 7-carboxy-7-deazaguanine synthase, Cx14CxxC-type
Occurring in:
  1. 7-carboxy-7-deazaguanine synthase
IPR024924
Domain description: 7-carboxy-7-deazaguanine synthase-like
Occurring in:
  1. 7-carboxy-7-deazaguanine synthase
IPR007197
Domain description: Radical SAM
Occurring in:
  1. 7-carboxy-7-deazaguanine synthase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. 7-carboxy-7-deazaguanine synthase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. 7-carboxy-7-deazaguanine synthase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. 7-carboxy-7-deazaguanine synthase
The deposited structure of PDB entry 4njg contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in 7-carboxy-7-deazaguanine synthase. Showing 1 copy in chain A.

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