Function and Biology Details
Reactions catalysed:
A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O
17-alpha-hydroxypregnenolone + [reduced NADPH--hemoprotein reductase] + O(2) = 3-beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Steroid 17-alpha-hydroxylase/17,20 lyase (preferred)
PDBe Complex ID:
PDB-CPX-138421 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Steroid 17-alpha-hydroxylase/17,20 lyase
Molecule details ›
Chains: A, B, C, D
Length: 494 amino acids
Theoretical weight: 55.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450
Length: 494 amino acids
Theoretical weight: 55.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P05093 (Residues: 24-508; Coverage: 96%)
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450
