› 4nlb

X-ray diffraction
2.4Å resolution

Crystal structure of the catalytic core of RRP6 from Trypanosoma brucei

Released:
DOI: 10.2210/pdb4nlb/pdb
PDB entry 4nlb coloured by chain, front view.
PDB entry 4nlb coloured by chain, side view.
PDB entry 4nlb coloured by chain, top view.
Source organism: Trypanosoma brucei brucei TREU927
Primary publication:
RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates.
Barbosa RL, Legrand P, Wien F, Pineau B, Thompson A, Guimarães BG
OpenAccess logo PLoS One 9 e89138 (2014)
PMID: 24558481

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176578 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HRDC domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 42.47 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
UniProt:
  • Canonical: Q581R8 (Residues: 176-540; Coverage: 51%)
Gene names: Tb04.2L9.1050, Tb927.4.1630
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 39.5Å b: 92.66Å c: 49.91Å
α: 90° β: 104.81° γ: 90°
R-values:
R R work R free
0.163 0.161 0.218
Expression system: Escherichia coli

Quick links

Citations

1 review citation

C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response.
Jackson et al. (2016)
3 other articles

2 mentions without citation

RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates.
Barbosa et al. (2014)
1 more