4nm8

X-ray diffraction
4Å resolution

Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-134653 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 323 amino acids
Theoretical weight: 35.51 KDa
Source organism: Influenza A virus (A/Hong Kong/1/1968(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q91MA7 (Residues: 27-345; Coverage: 58%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 176 amino acids
Theoretical weight: 20.2 KDa
Source organism: Influenza A virus (A/Hong Kong/1/1968(H3N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q91MA7 (Residues: 346-521; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B
Immunoglobulin kappa constant Chains: L, M, N
Molecule details ›
Chains: L, M, N
Length: 220 amino acids
Theoretical weight: 24.23 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: H, I, J
Molecule details ›
Chains: H, I, J
Length: 230 amino acids
Theoretical weight: 24.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: S6C4S0 (Residues: 20-245; Coverage: 88%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 241.491Å b: 142.355Å c: 170.725Å
α: 90° β: 133.46° γ: 90°
R-values:
R R work R free
0.242 0.24 0.292
Expression system: Trichoplusia ni