› 4np2

X-ray diffraction
1.75Å resolution

Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule

Released:
DOI: 10.2210/pdb4np2/pdb
PDB entry 4np2 coloured by chain, front view.
PDB entry 4np2 coloured by chain, side view.
PDB entry 4np2 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Fragment-based identification of an inducible binding site on cell surface receptor CD44 for the design of protein-carbohydrate interaction inhibitors.
Liu LK, Finzel BC
J Med Chem 57 2714-25 (2014)
PMID: 24606063

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD44 antigen Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 16.72 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15379 (Residues: 23-171; Coverage: 20%)
Gene names: Cd44, Ly-24
Sequence domains: Extracellular link domain

Ligands and Environments

4 bound ligands:
Ligand 2L1 1 x 2L1
Ligand MES 1 x MES
Ligand SO4 2 x SO4
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 30.97Å b: 82.16Å c: 32.04Å
α: 90° β: 117.84° γ: 90°
R-values:
R R work R free
0.177 0.174 0.217
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Carcinoma Cell Hyaluronan as a "Portable" Cancerized Prometastatic Microenvironment.
Turley et al. (2016)
2 more