4nrx

X-ray diffraction
2.21Å resolution

Crystal Structure of HIV-1 Neutralizing Antibody m66 in complex with gp41 MPER peptide

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero dimer
PDBe Complex ID:
PDB-CPX-212825 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp41 Chains: C, P
Molecule details ›
Chains: C, P
Length: 19 amino acids
Theoretical weight: 2.35 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q9QQN5 (Residues: 91-109; Coverage: 16%)
Gene name: env
m66 Heavy Chain Chains: A, D, H
Molecule details ›
Chains: A, D, H
Length: 234 amino acids
Theoretical weight: 25.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
m66 Light Chain Chains: B, E, L
Molecule details ›
Chains: B, E, L
Length: 213 amino acids
Theoretical weight: 23.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 197.262Å b: 93.505Å c: 89.83Å
α: 90° β: 111.8° γ: 90°
R-values:
R R work R free
0.189 0.188 0.215
Expression systems:
  • Not provided
  • Homo sapiens