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Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum

X-ray diffraction
2.18Å resolution
PDB entry 4nxj coloured by chain, front view.
PDB entry 4nxj coloured by chain, side view.
PDB entry 4nxj coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bromo domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 7221.66 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-184806
Assembly 2
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Assembly Name: Bromo domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 7269.9 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-184806
Assembly 3
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Assembly Name: Bromo domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 7375.29 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-184806

Macromolecules

Bromo domain-containing protein
Chains: A, B, C
Length: 119 amino acids
Theoretical weight: 14.43 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IK82 (Residues: 8-125; Coverage: 16%)
Gene name: PF3D7_1475600
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
Bromo domain-containing protein in PDB entry 4nxj, assembly 1, front view.
Bromo domain-containing protein in PDB entry 4nxj, assembly 1, side view.
Bromo domain-containing protein in PDB entry 4nxj, assembly 1, top view.
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