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Structures of SAICAR Synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg2+, AIR and L-Asp

Source organism: Streptococcus pneumoniae TIGR4
Biochemical function: ligase activity
Biological process: cobalamin biosynthetic process
Cellular component: not assigned

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EC 6.3.2.6: Phosphoribosylaminoimidazolesuccinocarboxamide synthase

Reaction catalysed:
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate
Systematic name:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
Alternative Name(s):
  • 4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase
  • 4-(N-succinocarboxamide)-5-aminoimidazole synthetase
  • 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase
  • Phosphoribosylaminoimidazole-succinocarboxamide synthase
  • Phosphoribosylaminoimidazole-succinocarboxamide synthetase
  • Phosphoribosylaminoimidazolesuccinocarboxamide synthetase
  • PurC
  • SAICAR synthase
  • SAICAR synthetase
  • SAICARs

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01259
Domain description: SAICAR synthetase
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase
The deposited structure of PDB entry 4nye contains 2 copies of Pfam domain PF01259 (SAICAR synthetase) in Phosphoribosylaminoimidazole-succinocarboxamide synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018236
Domain description: SAICAR synthetase, conserved site
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase
IPR028923
Domain description: SAICAR synthetase/ADE2, N-terminal
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase
IPR033934
Domain description: Bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide synthase
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase
IPR001636
Domain description: Phosphoribosylaminoimidazole-succinocarboxamide synthase
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase
IPR036393
Domain description: Acetylglutamate kinase-like superfamily
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase

Structure domains

CATH CATH domains
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase
The deposited structure of PDB entry 4nye contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Phosphoribosylaminoimidazole-succinocarboxamide synthase. Showing 1 copy in chain A.
3.30.470.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: ATP-grasp fold, B domain
Occurring in:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase
The deposited structure of PDB entry 4nye contains 2 copies of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in Phosphoribosylaminoimidazole-succinocarboxamide synthase. Showing 1 copy in chain A.

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