EC 3.4.17.21: Glutamate carboxypeptidase II
Reaction catalysed:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
Systematic name:
-
Alternative Name(s):
- Acetylaspartylglutamate dipeptidase
- Folate hydrolase
- Folylpolyglutamate hydrolase
- MGCP
- Membrane glutamate carboxypeptidase
- Microsomal gamma-glutamyl carboxypeptidase
- N-acetylated alpha-linked acidic dipeptidase
- N-acetylated-alpha-linked-amino dipeptidase
- N-acetylated-gamma-linked-acidic dipeptidase
- N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)
- NAALA dipeptidase
- NAALADase
- PSM antigen
- PSMA
- Prostate-specific membrane antigen
- Prostrate-specific membrane antigen
- Pteroylpoly-gamma-glutamate carboxypeptidase
- Pteroylpoly-gamma-glutamate hydrolase
- Pteroylpolygammaglutamyl hydrolase
- Pteroylpolyglutamate hydrolase
- Pteroylpolyglutamic acid hydrolase
- Rat NAAG peptidase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR036757
Domain description:
Transferrin receptor-like, dimerisation domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
3.40.630.10
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Aminopeptidase
Homology:
Zn peptidases
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4oc3</span> contains 1 copy of CATH domain <span class='highlight'>3.40.630.10 (Aminopeptidase)</span> in <span class='highlight'>Glutamate carboxypeptidase 2</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4oc3 contains 1 copy of CATH domain 3.40.630.10 (Aminopeptidase) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4oc3_1_A_CATH_3.40.630.10_image-200x200.png)
1.20.930.40
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Transcription Elongation Factor S-II; Chain A
Homology:
Transferrin receptor-like, dimerisation domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>4oc3</span> contains 1 copy of CATH domain <span class='highlight'>1.20.930.40 (Transcription Elongation Factor S-II; Chain A)</span> in <span class='highlight'>Glutamate carboxypeptidase 2</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 4oc3 contains 1 copy of CATH domain 1.20.930.40 (Transcription Elongation Factor S-II; Chain A) in Glutamate carboxypeptidase 2. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/4oc3_1_A_CATH_1.20.930.40_image-200x200.png)