› 4odt

X-ray diffraction
1.95Å resolution

Fab Structure of lipid A-specific antibody S1-15 in complex with lipid A carbohydrate backbone

Released:
DOI: 10.2210/pdb4odt/pdb
PDB entry 4odt coloured by chain, front view.
PDB entry 4odt coloured by chain, side view.
PDB entry 4odt coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.
Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Kosma P, Brade H, Evans SV
J Biol Chem 290 19629-40 (2015)
PMID: 26085093

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213579 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
S1-15 Fab (IgG2b) heavy chain Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.35 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
S1-15 Fab (IgG2b kappa) light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.73 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: GP1, Z9M
Carbohydrate polymer
1 bound ligand:
Ligand PG0 4 x PG0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P43212
Unit cell:
a: 77.471Å b: 77.471Å c: 156.205Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.224

Quick links

Citations

4 citation in other articles

Interaction of Tryptophan- and Arginine-Rich Antimicrobial Peptide with E. coli Outer Membrane-A Molecular Simulation Approach.
Necula et al. (2023)
3 more

1 mention without citation

Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.
Haji-Ghassemi et al. (2015)