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Human GKRP bound to AMG-0771 and sorbitol-6-phosphate

Source organism: Homo sapiens
Biochemical function: glucose sensor activity
Biological process: carbohydrate derivative metabolic process
Cellular component: cytosol

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF20741
Domain description: C-terminal lid domain of glucokinase regulatory protein
Occurring in:
  1. Glucokinase regulatory protein
The deposited structure of PDB entry 4ohm contains 2 copies of Pfam domain PF20741 (C-terminal lid domain of glucokinase regulatory protein) in Glucokinase regulatory protein. Showing 1 copy in chain B.

PF22198
Domain description: Glucokinase regulatory protein, second SIS domain
Occurring in:
  1. Glucokinase regulatory protein

PF22645
Domain description: Glucokinase regulatory protein N-terminal SIS domain
Occurring in:
  1. Glucokinase regulatory protein

InterPro InterPro annotations
IPR001347
Domain description: SIS domain
Occurring in:
  1. Glucokinase regulatory protein
IPR046348
Domain description: SIS domain superfamily
Occurring in:
  1. Glucokinase regulatory protein
IPR005486
Domain description: Glucokinase regulatory protein, conserved site
Occurring in:
  1. Glucokinase regulatory protein
IPR040190
Domain description: N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein
Occurring in:
  1. Glucokinase regulatory protein

Structure domain

CATH CATH domain
3.40.50.10490
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glucose-6-phosphate isomerase like protein; domain 1
Occurring in:
  1. Glucokinase regulatory protein
The deposited structure of PDB entry 4ohm contains 2 copies of CATH domain 3.40.50.10490 (Rossmann fold) in Glucokinase regulatory protein. Showing 1 copy in chain B.

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