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X-ray diffraction
2.58Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171997 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucokinase regulatory protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 638 amino acids
Theoretical weight: 70.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14397 (Residues: 1-625; Coverage: 100%)
Gene name: GCKR
Sequence domains:
Structure domains: Glucose-6-phosphate isomerase like protein; domain 1

Ligands and Environments

5 bound ligands:
Ligand 2TG 2 x 2TG
Ligand S6P 2 x S6P
Ligand IOD 25 x IOD
Ligand GOL 1 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P65
Unit cell:
a: 148.923Å b: 148.923Å c: 132.394Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.207 0.269
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.
Raimondo et al. (2015)
4 more