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Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide

Source organism: Homo sapiens
Biochemical function: NAD+-protein poly-ADP-ribosyltransferase activity
Biological process: not assigned
Cellular component: not assigned

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EC 2.4.2.30: NAD(+) ADP-ribosyltransferase

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Systematic name:
NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Alternative Name(s):
  • ADP-ribosyltransferase (polymerizing)
  • NAD(+):poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
  • NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
  • Poly(ADP-ribose) synthase
  • Poly(ADP-ribose) synthetase
  • Poly(ADP-ribose)polymerase
  • Poly(adenosine diphosphate ribose) polymerase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00644
Domain description: Poly(ADP-ribose) polymerase catalytic domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of Pfam domain PF00644 (Poly(ADP-ribose) polymerase catalytic domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B [auth C].

PF02877
Domain description: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of Pfam domain PF02877 (Poly(ADP-ribose) polymerase, regulatory domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B [auth C].

PF05406
Domain description: WGR domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of Pfam domain PF05406 (WGR domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B [auth C].

PF08063
Domain description: PADR1 domain, zinc ribbon fold
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of Pfam domain PF08063 (PADR1 domain, zinc ribbon fold) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain A.

PF21728
Domain description: PADR1, N-terminal helical domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of Pfam domain PF21728 (PADR1, N-terminal helical domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain A.

PF00645
Domain description: Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of Pfam domain PF00645 (Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001510
Domain description: Zinc finger, PARP-type
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR008893
Domain description: WGR domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR012317
Domain description: Poly(ADP-ribose) polymerase, catalytic domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR004102
Domain description: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR036616
Domain description: Poly(ADP-ribose) polymerase, regulatory domain superfamily
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR012982
Domain description: PARP1-like, PADR1 domain, zinc ribbon fold
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR036930
Domain description: WGR domain superfamily
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR038650
Domain description: PADR1, C-terminal domain superfamily
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR047572
Domain description: PADR1 domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR036957
Domain description: Zinc finger, PARP-type superfamily
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus

Structure domains

CATH CATH domains
3.90.228.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Phosphoenolpyruvate Carboxykinase; domain 3
Homology: Phosphoenolpyruvate Carboxykinase; domain 3
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of CATH domain 3.90.228.10 (Phosphoenolpyruvate Carboxykinase; domain 3) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B [auth C].
1.20.142.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Poly(ADP-ribose) Polymerase; domain 1
Homology: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of CATH domain 1.20.142.10 (Poly(ADP-ribose) Polymerase; domain 1) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B [auth C].
3.30.1740.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: first zn-finger domain of poly(adp-ribose) polymerase-1
Homology: Zinc finger, PARP-type
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4oqa contains 2 copies of CATH domain 3.30.1740.10 (first zn-finger domain of poly(adp-ribose) polymerase-1) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain A.

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