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Crystal Structure of PRK1 Catalytic Domain in Complex with Lestaurtinib

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.11.13: Protein kinase C

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (diacylglycerol-dependent)
Alternative Name(s):
  • CPKC
  • CPKC-alpha
  • CPKC-beta
  • CPKC-gamma
  • Calcium-dependent protein kinase C
  • Calcium-independent protein kinase C
  • Calcium/phospholipid dependent protein kinase
  • NPKC
  • NPKC-delta
  • NPKC-epsilon
  • NPKC-eta
  • NPKC-theta
  • PKC
  • PKC-alpha
  • PKC-beta
  • PKC-delta
  • PKC-epsilon
  • PKC-gamma
  • PKC-zeta
  • Pkc1p
  • Protein kinase C-epsilon
  • STK24

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00433
Domain description: Protein kinase C terminal domain
Occurring in:
  1. Serine/threonine-protein kinase N1
The deposited structure of PDB entry 4otg contains 1 copy of Pfam domain PF00433 (Protein kinase C terminal domain) in Serine/threonine-protein kinase N1. Showing 1 copy in chain A.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase N1
The deposited structure of PDB entry 4otg contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Serine/threonine-protein kinase N1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000961
Domain description: AGC-kinase, C-terminal
Occurring in:
  1. Serine/threonine-protein kinase N1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase N1
IPR017892
Domain description: Protein kinase, C-terminal
Occurring in:
  1. Serine/threonine-protein kinase N1
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Serine/threonine-protein kinase N1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Serine/threonine-protein kinase N1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase N1

Structure domains

CATH CATH domains
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Serine/threonine-protein kinase N1
The deposited structure of PDB entry 4otg contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Serine/threonine-protein kinase N1. Showing 1 copy in chain A.
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Serine/threonine-protein kinase N1
The deposited structure of PDB entry 4otg contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Serine/threonine-protein kinase N1. Showing 1 copy in chain A.

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