› 4ow8

X-ray diffraction
2.03Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161609 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PknA Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 30.45 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WI83 (Residues: 1-283; Coverage: 66%)
Gene names: MTCY10H4.15c, Rv0015c, pknA
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Unit cell:
a: 54.139Å b: 58.412Å c: 78.867Å
α: 90° β: 96.2° γ: 90°
R-values:
R R work R free
0.228 0.226 0.275
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 citation in other articles

Mycobacterium tuberculosis serine/threonine protein kinases: structural information for the design of their specific ATP-competitive inhibitors.
Caballero et al. (2018)
6 more

4 mentions without citation

Potential Anti-Mycobacterium tuberculosis Activity of Plant Secondary Metabolites: Insight with Molecular Docking Interactions.
Kumar et al. (2021)
3 more