› 4oyf

X-ray diffraction
3.41Å resolution

Crystal structure of GLTPH R397A IN Sodium-bound state

Released:
DOI: 10.2210/pdb4oyf/pdb
PDB entry 4oyf coloured by chain, front view.
PDB entry 4oyf coloured by chain, side view.
PDB entry 4oyf coloured by chain, top view.
Source organism: Pyrococcus horikoshii
Primary publication:
Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Verdon G, Oh S, Serio RN, Boudker O
OpenAccess logo Elife 3 e02283 (2014)
PMID: 24842876

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129795 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate transporter homolog Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 422 amino acids
Theoretical weight: 44.64 KDa
Source organism: Pyrococcus horikoshii
Expression system: Escherichia coli
UniProt:
  • Canonical: O59010 (Residues: 1-419; Coverage: 99%)
Gene name: PH1295
Sequence domains: Sodium:dicarboxylate symporter family
Structure domains: Sodium:dicarboxylate symporter

Ligands and Environments

1 bound ligand:
Ligand NA 6 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P31
Unit cell:
a: 110.579Å b: 110.579Å c: 306.923Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.285 0.284 0.293
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Shared Molecular Mechanisms of Membrane Transporters.
Drew et al. (2016)
9 more

10 mentions without citation

Elevator-type mechanisms of membrane transport.
Garaeva et al. (2020)
9 more