4ozi › Citations

T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.

Petersen J, Montserrat V, Mujico JR, Loh KL, Beringer DX, van Lummel M, Thompson A, Mearin ML, Schweizer J, Kooy-Winkelaar Y, van Bergen J, Drijfhout JW, Kan WT, La Gruta NL, Anderson RP, Reid HH, Koning F, Rossjohn J
Nat Struct Mol Biol 21 480-8 (2014)
Related entries: 4ozf, 4ozg, 4ozh

Cited: 110 times
EuropePMC logo PMID: 24777060

Abstract

Celiac disease is a T cell-mediated disease induced by dietary gluten, a component of which is gliadin. 95% of individuals with celiac disease carry the HLA (human leukocyte antigen)-DQ2 locus. Here we determined the T-cell receptor (TCR) usage and fine specificity of patient-derived T-cell clones specific for two epitopes from wheat gliadin, DQ2.5-glia-α1a and DQ2.5-glia-α2. We determined the ternary structures of four distinct biased TCRs specific for those epitopes. All three TCRs specific for DQ2.5-glia-α2 docked centrally above HLA-DQ2, which together with mutagenesis and affinity measurements provided a basis for the biased TCR usage. A non-germline encoded arginine residue within the CDR3β loop acted as the lynchpin within this common docking footprint. Although the TCRs specific for DQ2.5-glia-α1a and DQ2.5-glia-α2 docked similarly, their interactions with the respective gliadin determinants differed markedly, thereby providing a basis for epitope specificity.

Reviews - 4ozi mentioned but not cited (2)

  1. The Many Faces of CD4+ T Cells: Immunological and Structural Characteristics. Chatzileontiadou DSM, Sloane H, Nguyen AT, Gras S, Grant EJ. Int J Mol Sci 22 E73 (2020)
  2. Coevolution of T-cell receptors with MHC and non-MHC ligands. Castro CD, Luoma AM, Adams EJ. Immunol Rev 267 30-55 (2015)

Articles - 4ozi mentioned but not cited (10)



Reviews citing this publication (27)

  1. T cell antigen receptor recognition of antigen-presenting molecules. Rossjohn J, Gras S, Miles JJ, Turner SJ, Godfrey DI, McCluskey J. Annu Rev Immunol 33 169-200 (2015)
  2. HLA variation and disease. Dendrou CA, Petersen J, Rossjohn J, Fugger L. Nat Rev Immunol 18 325-339 (2018)
  3. Understanding the drivers of MHC restriction of T cell receptors. La Gruta NL, Gras S, Daley SR, Thomas PG, Rossjohn J. Nat Rev Immunol 18 467-478 (2018)
  4. Variations in MHC Class II Antigen Processing and Presentation in Health and Disease. Unanue ER, Turk V, Neefjes J. Annu Rev Immunol 34 265-297 (2016)
  5. T Cells in Celiac Disease. Jabri B, Sollid LM. J Immunol 198 3005-3014 (2017)
  6. The roles of MHC class II genes and post-translational modification in celiac disease. Sollid LM. Immunogenetics 69 605-616 (2017)
  7. Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes. Singh NK, Riley TP, Baker SCB, Borrman T, Weng Z, Baker BM. J Immunol 199 2203-2213 (2017)
  8. Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Sollid LM, Pos W, Wucherpfennig KW. Curr Opin Immunol 31 24-30 (2014)
  9. Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens. Koning F, Thomas R, Rossjohn J, Toes RE. Nat Rev Rheumatol 11 450-461 (2015)
  10. T-cell and B-cell immunity in celiac disease. du Pré MF, Sollid LM. Best Pract Res Clin Gastroenterol 29 413-423 (2015)
  11. Coeliac disease: a unique model for investigating broken tolerance in autoimmunity. Hardy MY, Tye-Din JA. Clin Transl Immunology 5 e112 (2016)
  12. Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism. Kumar V, Wijmenga C, Xavier RJ. Curr Opin Immunol 31 51-57 (2014)
  13. Why Oats Are Safe and Healthy for Celiac Disease Patients. Gilissen LJWJ, van der Meer IM, Smulders MJM. Med Sci (Basel) 4 E21 (2016)
  14. CRISPR/Cas9 Gene Editing of Gluten in Wheat to Reduce Gluten Content and Exposure-Reviewing Methods to Screen for Coeliac Safety. Jouanin A, Gilissen LJWJ, Schaart JG, Leigh FJ, Cockram J, Wallington EJ, Boyd LA, van den Broeck HC, van der Meer IM, America AHP, Visser RGF, Smulders MJM. Front Nutr 7 51 (2020)
  15. Local communication among mucosal immune cells in patients with celiac disease. van Bergen J, Mulder CJ, Mearin ML, Koning F. Gastroenterology 148 1187-1194 (2015)
  16. Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity. Scherf KA, Catassi C, Chirdo F, Ciclitira PJ, Feighery C, Gianfrani C, Koning F, Lundin KEA, Schuppan D, Smulders MJM, Tranquet O, Troncone R, Koehler P. Front Nutr 7 29 (2020)
  17. Coeliac disease - from genetic and immunological studies to clinical applications. Lundin KE, Qiao SW, Snir O, Sollid LM. Scand J Gastroenterol 50 708-717 (2015)
  18. Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1. Awad W, Le Nours J, Kjer-Nielsen L, McCluskey J, Rossjohn J. Immunol Cell Biol 96 588-597 (2018)
  19. Transglutaminase 2 and Transglutaminase 2 Autoantibodies in Celiac Disease: a Review. Rauhavirta T, Hietikko M, Salmi T, Lindfors K. Clin Rev Allergy Immunol 57 23-38 (2019)
  20. Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis. McLaughlin RJ, Spindler MP, van Lummel M, Roep BO. Curr Diab Rep 16 63 (2016)
  21. Common ground: shared risk factors for type 1 diabetes and celiac disease. Verdu EF, Danska JS. Nat Immunol 19 685-695 (2018)
  22. Beyond the HLA Genes in Gluten-Related Disorders. Sallese M, Lopetuso LR, Efthymakis K, Neri M. Front Nutr 7 575844 (2020)
  23. TCR-like antibodies targeting autoantigen-mhc complexes: a mini-review. Li Y, Jiang W, Mellins ED. Front Immunol 13 968432 (2022)
  24. The Link between Autoimmunity and Lymphoma: Does NOTCH Signaling Play a Contributing Role? Kuksin CA, Minter LM. Front Oncol 5 51 (2015)
  25. Why are western diet and western lifestyle pro-inflammatory risk factors of celiac disease? Skoracka K, Hryhorowicz S, Rychter AM, Ratajczak AE, Szymczak-Tomczak A, Zawada A, Słomski R, Dobrowolska A, Krela-Kaźmierczak I. Front Nutr 9 1054089 (2022)
  26. Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease. Lindeman I, Sollid LM. Mucosal Immunol 15 51-63 (2022)
  27. An Interpretable Classification Model Using Gluten-Specific TCR Sequences Shows Diagnostic Potential in Coeliac Disease. Fowler A, FitzPatrick M, Shanmugarasa A, Ibrahim ASF, Kockelbergh H, Yang HC, Williams-Walker A, Luu Hoang KN, Evans S, Provine N, Klenerman P, Soilleux EJ. Biomolecules 13 1707 (2023)

Articles citing this publication (71)



Quick links